SCHEMBL27317141

SCHEMBL27317141

Cn1ncc(-c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c1-c1cccc(F)c1

nearest known ligand 0.53

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 15/20 0.53
▸ IKZF2 Q9UKS7 4/20 0.49
▸ IKZF1 Q13422 1/20 0.48
▸ CSNK1A1 P48729 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27317230 0.92 CRBN (0.55) CRBNIKZF2IKZF1
SCHEMBL27216930 0.92 CRBN (0.55) CRBNIKZF2IKZF1
SCHEMBL27316090 0.91 CRBN (0.56) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL27217151 0.91 CRBN (0.60) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL27317436 0.90 CRBN (0.62) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL27317074 0.90 CRBN (0.54) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL27318724 0.90 CRBN (0.62) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL27317139 0.90 CRBN (0.53) CRBNIKZF2IKZF1
SCHEMBL27317312 0.90 CRBN (0.59) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL27317075 0.90 CRBN (0.52) CRBNIKZF2IKZF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024054832-A1 CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. (US) 2024-03-14 — — WO disclosed
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