Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 12/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 12/20 | 0.55 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | MBOAT4 | Q96T53 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26060781 | 0.83 | NR1I3 (0.50) | GRIN1GRIN2BNR1I3CDK5CDK5R1 | |
| SCHEMBL10878141 | 0.83 | NR1I3 (0.50) | GRIN1GRIN2BNR1I3CDK5CDK5R1 | |
| SCHEMBL11580475 | 0.83 | NR1I3 (0.50) | GRIN1GRIN2BNR1I3CDK5CDK5R1 | |
| SCHEMBL10878132 | 0.83 | NR1I3 (0.50) | GRIN1GRIN2BNR1I3CDK5CDK5R1 | |
| SCHEMBL2195019 | 0.81 | CDK5 (0.48) | GRIN1GRIN2BNR1I3CDK5CDK5R1 | |
| SCHEMBL31620148 | 0.81 | NR1I3 (0.48) | GRIN1GRIN2BNR1I3CDK5CDK5R1 | |
| SCHEMBL947528 | 0.80 | CDK5 (0.47) | GRIN1GRIN2BNR1I3CDK5CDK5R1 | |
| SCHEMBL27420941 | 0.79 | ALDH1A1 (0.50) | GRIN1GRIN2BNR1I3CYP19A1GRIN2D | |
| SCHEMBL10886062 | 0.78 | CDK5 (0.48) | GRIN1GRIN2BNR1I3CDK5CDK5R1 | |
| SCHEMBL10886068 | 0.78 | CDK5 (0.48) | GRIN1GRIN2BNR1I3CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102884072-A | Substituted androst-4-ene diones | UNIV EMORY | 2013-01-16 | — | — | CN | disclosed |
| CN-100393360-C | Compositon comprising a combination of an aromatase inhibitor, a progestin and an oestrogen and its use for the treatment of endometriosis | ASTRAZENECA AB (SE) | 2008-06-11 | — | — | CN | disclosed |
| CN-1747736-A | Compositon comprising a combination of an aromatase inhibitor, a progestin and an oestrogen and its use for the treatment of endometriosis | ASTRAZENECA AB (SE) | 2006-03-15 | — | — | CN | disclosed |
| CN-1104243-C | Use of aromatase inhibitors in the prepn. of a drug for treating a relative androgend effciency in men | SCHERING AG (DE) | 2003-04-02 | — | — | CN | disclosed |
| CN-1178463-A | Use of anti-oestrogens as male contraceptives | SCHERING AG (DE) | 1998-04-08 | — | — | CN | disclosed |
| CN-1158570-A | Use of aromatase inhibitors for producing a medicament for treating a relative androgen deficiency in men | SCHERING AG (DE) | 1997-09-03 | — | — | CN | disclosed |
| CN-1047298-A | The application of gestodene in medication preparation | SCHERING AG (DE) | 1990-11-28 | — | — | CN | disclosed |