Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | CHKA | P35790 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.44 |
| ▸ | ILK | Q13418 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25728287 | 0.88 | CHKA (0.59) | HRH3KCNH2CHKACYP1A2LMNA | |
| SCHEMBL31428715 | 0.87 | HRH3 (0.49) | HRH3KCNH2CYP1A2SMN1; SMN2HTT | |
| SCHEMBL24694886 | 0.87 | HRH3 (0.47) | HRH3KCNH2CYP1A2KMT2A | |
| SCHEMBL30163474 | 0.84 | KMT2A (0.56) | HRH3KCNH2CHKACYP1A2ALDH1A1 | |
| SCHEMBL27110695 | 0.81 | POLB (0.53) | HRH3CHKAALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL25727251 | 0.81 | CHKA (0.48) | HRH3KCNH2CHKAALDH1A1POLB | |
| SCHEMBL27318964 | 0.80 | ACHE (0.53) | HRH3KCNH2CYP1A2POLBKDM4E | |
| SCHEMBL31428837 | 0.80 | HRH3 (0.45) | HRH3KCNH2CHKACYP1A2KMT2A | |
| SCHEMBL27953064 | 0.80 | HRH3 (0.50) | HRH3CHKAALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL25727261 | 0.80 | CHKA (0.47) | HRH3CHKAALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024006881-A1 | WEE1 DEGRADING COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-01-04 | — | — | WO | disclosed |