SCHEMBL27318486

SCHEMBL27318486

C[Si](C)(C)CCOCn1cc(C#N)nc1C#N

nearest known ligand 0.42

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 3/20 0.37
RPS6KB1 P23443 1/20 0.33
PDE10A Q9Y233 4/20 0.31
BRD4 O60885 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12000815 0.85 DGAT1 (0.39) DGAT1RPS6KB1PDE10ABRD4
SCHEMBL15315929 0.85 DGAT1 (0.39) DGAT1PDE10A
SCHEMBL10291486 0.84 DGAT1 (0.36) DGAT1RPS6KB1PDE10A
SCHEMBL1858224 0.84 DGAT1 (0.41) DGAT1RPS6KB1PDE10A
SCHEMBL25300404 0.84 DGAT1 (0.44) DGAT1PDE10A
SCHEMBL9958547 0.81 DGAT1 (0.55) DGAT1PDE10A
SCHEMBL18431168 0.80 DGAT1 (0.35) DGAT1
SCHEMBL2934571 0.79 DGAT1 (0.36) DGAT1BRD4
SCHEMBL16188918 0.79 DGAT1 (0.34) DGAT1BRD4
SCHEMBL21028220 0.78 DGAT1 (0.33) DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1049341-A AZOLE PESTICIDES SCHERING AGROCHEMICALS LTD (GB) 1991-02-20 CN disclosed