SCHEMBL27323246

SCHEMBL27323246

BC(B)(O)n1cc(-c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)nc1-c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 9/20 0.52
▸ CSNK1A1 P48729 3/20 0.51
▸ IKZF1 Q13422 3/20 0.50
▸ IKZF2 Q9UKS7 6/20 0.46
▸ MAP1LC3B Q9GZQ8 1/20 0.45
▸ GSPT1 P15170 1/20 0.43
▸ SALL4 Q9UJQ4 1/20 0.43
▸ IKZF3 Q9UKT9 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27216923 0.86 CRBN (0.56) CRBNCSNK1A1IKZF1IKZF2
SCHEMBL30801574 0.86 CRBN (0.56) CRBNCSNK1A1IKZF1IKZF2
SCHEMBL27216961 0.85 CRBN (0.55) CRBNCSNK1A1IKZF1IKZF2MAP1LC3B
SCHEMBL30801563 0.85 CRBN (0.55) CRBNCSNK1A1IKZF1IKZF2MAP1LC3B
SCHEMBL27312418 0.85 CRBN (0.55) CRBNCSNK1A1IKZF1IKZF2
SCHEMBL30801575 0.84 CRBN (0.53) CRBNCSNK1A1IKZF1IKZF2
SCHEMBL27217070 0.83 CRBN (0.53) CRBNCSNK1A1IKZF1IKZF2
SCHEMBL27217199 0.83 CRBN (0.53) CRBNCSNK1A1IKZF1IKZF2
SCHEMBL27216986 0.83 CRBN (0.56) CRBNCSNK1A1IKZF1IKZF2
SCHEMBL27312417 0.81 CRBN (0.53) CRBNCSNK1A1IKZF1IKZF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024054832-A1 CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. (US) 2024-03-14 — — WO disclosed
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