Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25942017 | 0.88 | SOS1 (0.39) | SOS1GPR119LMNAPKMNPC1 | |
| SCHEMBL16302793 | 0.84 | SOS1 (0.41) | SOS1LMNAPKMNPC1RAB9A | |
| SCHEMBL25942185 | 0.79 | GAA (0.38) | SOS1LMNAPKMHTTALDH1A1 | |
| SCHEMBL27326951 | 0.79 | SOS1 (0.37) | SOS1LMNAPKMNPC1RAB9A | |
| SCHEMBL31532466 | 0.78 | TSHR (0.33) | GPR119SLC6A2SLC6A3CYP2D6CYP2C19 | |
| SCHEMBL2512338 | 0.76 | GPR119 (0.41) | GPR119LMNANPC1RAB9AHTT | |
| SCHEMBL16303842 | 0.76 | SMN1; SMN2 (0.42) | SOS1LMNAPKMNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL15231570 | 0.74 | S1PR1 (0.45) | LMNAPKMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27326291 | 0.72 | CXCR4 (0.37) | SOS1SIGMAR1CXCR4ALDH1A1 | |
| SCHEMBL25946436 | 0.72 | CACNA1H (0.42) | GPR119SLC6A2SLC6A3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024088922-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MONOACYLGLYCEROL LIPASE (MAGL) | F. HOFFMANN-LA ROCHE AG (CH) | 2024-05-02 | — | — | WO | disclosed |