Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NRAS | P01111 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 7/20 | 0.34 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | ABL1 | P00519 | 3/20 | 0.32 |
| ▸ | EGFR | P00533 | 3/20 | 0.32 |
| ▸ | HCK | P08631 | 3/20 | 0.32 |
| ▸ | SRC | P12931 | 3/20 | 0.32 |
| ▸ | KDR | P35968 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.32 |
| ▸ | MTOR | P42345 | 3/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.32 |
| ▸ | PRKDC | P78527 | 3/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27332713 | 0.96 | NRAS (0.36) | NRASFLT3TNK2TRPC6FYN | |
| SCHEMBL31639175 | 0.83 | NRAS (0.36) | NRASFLT3TRPC6PIK3CAMTOR | |
| SCHEMBL31000231 | 0.79 | NRAS (0.34) | NRASFLT3TRPC6PIK3CAMTOR | |
| SCHEMBL27327563 | 0.79 | NRAS (0.33) | NRASFLT3PIK3CAFYN | |
| SCHEMBL31739941 | 0.79 | NRAS (0.44) | NRASFLT3 | |
| SCHEMBL31740008 | 0.79 | NRAS (0.55) | NRASFLT3PDGFRBPDGFRAABL1 | |
| SCHEMBL27326957 | 0.79 | NRAS (0.44) | NRASFLT3 | |
| SCHEMBL27330153 | 0.79 | NRAS (0.55) | NRASFLT3PDGFRBPDGFRAABL1 | |
| SCHEMBL27329557 | 0.79 | NRAS (0.44) | NRASFLT3 | |
| SCHEMBL31739826 | 0.78 | NRAS (0.44) | NRASFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023245123-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-12-21 | — | — | WO | disclosed |