Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732226 | 0.85 | JAK2 (0.65) | KMT2AJAK2JAK1MEN1NPSR1 | |
| SCHEMBL18424508 | 0.83 | KMT2A (0.56) | KMT2AJAK2JAK1OPRM1SIGMAR1 | |
| SCHEMBL144125 | 0.82 | KMT2A (0.51) | KMT2AJAK2JAK1OPRM1SIGMAR1 | |
| SCHEMBL785972 | 0.77 | JAK2 (0.54) | KMT2AJAK2JAK1OPRM1SIGMAR1 | |
| SCHEMBL2731227 | 0.76 | KMT2A (0.44) | KMT2AJAK2JAK1OPRM1SIGMAR1 | |
| SCHEMBL16192363 | 0.75 | JAK2 (0.74) | KMT2AJAK2JAK1OPRM1SIGMAR1 | |
| SCHEMBL28568037 | 0.75 | JAK2 (0.64) | KMT2AJAK2JAK1OPRM1SIGMAR1 | |
| SCHEMBL28568035 | 0.75 | JAK2 (0.64) | KMT2AJAK2JAK1OPRM1SIGMAR1 | |
| SCHEMBL17274372 | 0.75 | NAAA (0.63) | KMT2AJAK2JAK1HDAC1MCHR1 | |
| SCHEMBL13132647 | 0.74 | GRIN2B (0.49) | KMT2AOPRM1SIGMAR1HDAC1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632898-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | Biogen Idec MA Inc. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058645-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. (US) | 2012-05-03 | — | — | WO | disclosed |