Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.33 |
| ▸ | NCF1 | P14598 | 3/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | SOD3 | P08294 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14930383 | 0.83 | PDCD1 (0.50) | PDCD1CD274HTR2CHTR2AADRB1 | |
| SCHEMBL26495272 | 0.79 | HTR2C (0.35) | PDCD1CD274HTR2CHTR2ACHRNB2 | |
| SCHEMBL24417833 | 0.78 | HTR2C (0.37) | PDCD1CD274HTR2CHTR2ANCF1 | |
| SCHEMBL20517214 | 0.78 | HTR2C (0.37) | PDCD1CD274HTR2CHTR2ACHRNB2 | |
| SCHEMBL27329663 | 0.77 | HTR2C (0.34) | PDCD1CD274HTR2CHTR2A | |
| SCHEMBL25594644 | 0.77 | GRM5 (0.40) | PDCD1CD274HTR2CHTR2AADRB1 | |
| SCHEMBL2928676 | 0.76 | — | — | |
| SCHEMBL25772024 | 0.73 | PDE10A (0.41) | — | |
| SCHEMBL25827027 | 0.73 | PDE10A (0.41) | — | |
| SCHEMBL16814033 | 0.73 | PDCD1 (0.42) | PDCD1CD274HTR2CHTR2ANCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024015251-A1 | INHIBITORS OF HPK1 AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. (US) | 2024-01-18 | — | — | WO | disclosed |