Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20053916 | 0.85 | PDCD1 (0.44) | HTR2CHTR2APDCD1CD274MAP4K1 | |
| SCHEMBL26549023 | 0.79 | NUDT1 (0.34) | — | |
| SCHEMBL27329671 | 0.77 | PDCD1 (0.37) | HTR2CHTR2APDCD1CD274 | |
| SCHEMBL20460995 | 0.75 | PDCD1 (0.36) | PDCD1CD274MAP4K1LRRK2 | |
| SCHEMBL26495272 | 0.75 | HTR2C (0.35) | HTR2CHTR2APDCD1CD274HTR2B | |
| SCHEMBL24417833 | 0.74 | HTR2C (0.37) | HTR2CHTR2APDCD1CD274 | |
| SCHEMBL20517214 | 0.74 | HTR2C (0.37) | HTR2CHTR2APDCD1CD274 | |
| SCHEMBL25594644 | 0.73 | GRM5 (0.40) | HTR2CHTR2APDCD1CD274HTR2B | |
| SCHEMBL27054804 | 0.69 | ROCK2 (0.39) | LRRK2 | |
| SCHEMBL21017741 | 0.68 | PDCD1 (0.41) | HTR2CHTR2APDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024015251-A1 | INHIBITORS OF HPK1 AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. (US) | 2024-01-18 | — | — | WO | disclosed |