Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3971910 | 0.80 | POLB (0.51) | TP53POLBL3MBTL1LMNAMAPK1 | |
| SCHEMBL1110064 | 0.71 | POLB (0.54) | TP53POLBL3MBTL1LMNAMAPK1 | |
| SCHEMBL4256475 | 0.68 | POLB (0.51) | TP53POLBL3MBTL1LMNAMAPK1 | |
| SCHEMBL14919416 | 0.68 | POLB (0.51) | TP53POLBL3MBTL1LMNAMAPK1 | |
| SCHEMBL28668767 | 0.66 | POLB (0.52) | TP53POLBL3MBTL1LMNAMAPK1 | |
| SCHEMBL31098382 | 0.66 | SMN1; SMN2 (0.50) | LMNAMAPK1RAB9AMAPTTSHR | |
| SCHEMBL16503885 | 0.64 | POLB (0.47) | TP53POLBL3MBTL1LMNAMAPK1 | |
| SCHEMBL28929688 | 0.63 | MAPT (0.56) | TP53POLBL3MBTL1LMNAMAPK1 | |
| SCHEMBL28670431 | 0.62 | CFTR (0.50) | TP53POLBL3MBTL1LMNAMAPK1 | |
| SCHEMBL28677624 | 0.62 | UTS2R (0.57) | TP53POLBL3MBTL1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632465-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058116-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |