Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 10/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10286951 | 0.84 | KCNJ1 (0.40) | KCNJ1KDM4EALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL2733015 | 0.83 | KCNJ1 (0.39) | KCNJ1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2733687 | 0.83 | GPR119 (0.39) | — | |
| SCHEMBL2733149 | 0.80 | KCNJ1 (0.35) | KCNJ1TAAR1DRD1 | |
| SCHEMBL299486 | 0.77 | KCNJ1 (0.38) | KCNJ1TAAR1DRD1 | |
| SCHEMBL2897011 | 0.73 | KCNJ1 (0.42) | KCNJ1KDM4EALDH1A1TAAR1DRD1 | |
| SCHEMBL4549724 | 0.72 | KCNJ1 (0.58) | KCNJ1 | |
| SCHEMBL4549586 | 0.70 | KCNJ1 (0.60) | KCNJ1 | |
| SCHEMBL4549585 | 0.70 | KCNJ1 (0.60) | KCNJ1 | |
| SCHEMBL2732158 | 0.67 | GPR119 (0.42) | KCNJ1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632464-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |