Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 12/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15018201 | 0.84 | KCNJ1 (0.49) | KCNJ1ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL14785751 | 0.77 | ALDH1A1 (0.56) | KCNJ1ALDH1A1KMT2AMAPTTP53 | |
| SCHEMBL2729430 | 0.75 | KCNJ1 (0.65) | KCNJ1ALDH1A1KMT2AMAPT | |
| SCHEMBL15018034 | 0.74 | KCNJ1 (0.49) | KCNJ1ALDH1A1KMT2AMAPTMEN1 | |
| SCHEMBL2733215 | 0.73 | KCNJ1 (0.49) | KCNJ1 | |
| SCHEMBL15018095 | 0.70 | KMT2A (0.46) | KCNJ1ALDH1A1KMT2AMAPTTP53 | |
| SCHEMBL17303140 | 0.70 | KCNJ1 (0.46) | KCNJ1ALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL2732399 | 0.69 | KCNJ1 (0.47) | KCNJ1KMT2ATP53MEN1 | |
| SCHEMBL16906605 | 0.69 | KCNJ1 (1.00) | KCNJ1ALDH1A1KMT2AMAPTTP53 | |
| SCHEMBL16897509 | 0.68 | KCNJ1 (1.00) | KCNJ1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632464-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |