Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27333064 | 1.00 | HPGD (0.45) | HPGDFFAR1BRD4PDE3BPDE3A | |
| SCHEMBL27342090 | 0.97 | HPGD (0.45) | HPGDFFAR1BRD4PDE3BPDE3A | |
| SCHEMBL27432152 | 0.97 | HPGD (0.45) | HPGDFFAR1BRD4PDE3BPDE3A | |
| SCHEMBL27342692 | 0.90 | HPGD (0.45) | HPGDPDE3BPDE3AP2RY12ALDH1A1 | |
| SCHEMBL27523082 | 0.90 | ALDH1A1 (0.47) | HPGDPDE3BPDE3AP2RY12ALDH1A1 | |
| SCHEMBL8724019 | 0.88 | HPGD (0.48) | HPGDFFAR1PDE3BPDE3AP2RY12 | |
| SCHEMBL8724013 | 0.88 | HPGD (0.48) | HPGDFFAR1PDE3BPDE3AP2RY12 | |
| SCHEMBL8724010 | 0.88 | HPGD (0.48) | HPGDFFAR1PDE3BPDE3AP2RY12 | |
| SCHEMBL7446627 | 0.87 | HPGD (0.47) | HPGDFFAR1PDE3BPDE3AP2RY12 | |
| SCHEMBL7446615 | 0.87 | HPGD (0.47) | HPGDFFAR1PDE3BPDE3AP2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1043765-C | Positive inotropic and lusitropic pyrroloquinolinone derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1999-06-23 | — | — | CN | disclosed |
| CN-1125945-A | Positive inotropic and lusitropic pyrroloquinolinone derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1996-07-03 | — | — | CN | disclosed |