Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14738495 | 1.00 | CYP3A4 (0.43) | CYP3A4ALOX15 | |
| SCHEMBL2732951 | 0.98 | CYP3A4 (0.42) | CYP3A4ALOX15 | |
| SCHEMBL15370116 | 0.82 | CYP3A4 (0.36) | CYP3A4ALOX15 | |
| SCHEMBL11300845 | 0.80 | CYP3A4 (0.35) | CYP3A4ALOX15 | |
| SCHEMBL1308974 | 0.79 | — | — | |
| SCHEMBL15370119 | 0.79 | CYP3A4 (0.34) | CYP3A4ALOX15 | |
| SCHEMBL2731989 | 0.79 | CYP3A4 (0.34) | CYP3A4ALOX15 | |
| SCHEMBL15407395 | 0.77 | CYP3A4 (0.32) | CYP3A4ALOX15 | |
| SCHEMBL11892640 | 0.77 | CYP3A4 (0.32) | CYP3A4ALOX15 | |
| SCHEMBL15363844 | 0.77 | CYP3A4 (0.33) | CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2704568-B1 | DIAZENIUMDIOLATE CYCLOHEXYL DERIVATIVES | MERCK SHARP & DOHME (US) | 2018-01-24 | — | — | EP | claimed |
| EP-2632255-B1 | DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES | MERCK SHARP & DOHME (US) | 2017-06-21 | — | — | EP | claimed |
| EP-2704568-A1 | DIAZENIUMDIOLATE CYCLOHEXYL DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2014-03-12 | — | — | EP | claimed |
| EP-2632255-A1 | DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | claimed |
| WO-2012151114-A1 | DIAZENIUMDIOLATE CYCLOHEXYL DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-11-08 | — | — | WO | claimed |
| WO-2012058203-A1 | DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | claimed |
| EP-2571351-B1 | DIAZENIUMDIOLATE CYCLOHEXYL DERIVATIVES | MERCK SHARP & DOHME (US) | 2016-09-14 | — | — | EP | disclosed |
| EP-2704568-A1 | DIAZENIUMDIOLATE CYCLOHEXYL DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2014-03-12 | — | — | EP | disclosed |
| US-8623846-B2 | Diazeniumdiolate cyclohexyl derivatives | MERCK SHARP & DOHME CORP. (US) | 2014-01-07 | — | — | US | disclosed |
| EP-2632255-A1 | DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| US-20130059823-A1 | Diazeniumdiolate Cyclohexyl Derivatives | MERCK SHARP & DOHME LLC | 2013-03-07 | — | — | US | disclosed |
| EP-2533644-A1 | DIAZENIUMDIOLATE CYCLOPENTYL DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2012151114-A1 | DIAZENIUMDIOLATE CYCLOHEXYL DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-11-08 | — | — | WO | disclosed |
| WO-2012058203-A1 | DIAZENIUMDIOLATE HETEROCYCLIC DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059823-A1 | Diazeniumdiolate Cyclohexyl Derivatives | OR10J3, CBR3, CBR1 | CYP3A4 684/4885ALOX15 3521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.