Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733833 | 0.85 | NPC1 (0.44) | MAPTALDH1A1SMN1; SMN2L3MBTL1TDP1 | |
| SCHEMBL40548 | 0.84 | KDM5A (0.49) | MAPTNPSR1CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL6000696 | 0.79 | MAPT (0.44) | MAPTNPSR1CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL39747 | 0.79 | SIRT6 (0.49) | MAPTNPSR1CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL39927 | 0.76 | HPGD (0.49) | MAPTNPSR1CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL39772 | 0.76 | SERPINE1 (0.47) | MAPTALDH1A1MAPK1HTTTDP1 | |
| SCHEMBL46697 | 0.76 | HPGD (0.60) | MAPTNPSR1CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL39825 | 0.75 | HPGD (0.52) | MAPTNPSR1CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL40086 | 0.75 | SERPINE1 (0.47) | MAPTCYP1A2CYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL15432542 | 0.74 | MAPT (0.43) | MAPTNPSR1CYP1A2CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |