Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.44 |
| ▸ | FLT4 | P35916 | 4/20 | 0.44 |
| ▸ | FLT3 | P36888 | 4/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.44 |
| ▸ | HIPK4 | Q8NE63 | 4/20 | 0.44 |
| ▸ | RET | P07949 | 4/20 | 0.44 |
| ▸ | PLK4 | O00444 | 3/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.44 |
| ▸ | MET | P08581 | 3/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.44 |
| ▸ | FLT1 | P17948 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | BLK | P51451 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794432 | 0.86 | KDR (0.63) | KDRROCK2AURKBEPHA2FLT4 | |
| SCHEMBL5880331 | 0.83 | KDR (0.55) | KDRROCK2AURKBEPHA2FLT4 | |
| SCHEMBL5750826 | 0.78 | KDR (0.51) | KDRROCK2AURKBEPHA2FLT4 | |
| SCHEMBL2732814 | 0.78 | KDR (0.56) | KDRROCK2AURKBEPHA2FLT4 | |
| SCHEMBL2733951 | 0.77 | KDR (0.55) | KDRROCK2AURKBEPHA2FLT4 | |
| SCHEMBL2732944 | 0.76 | KDR (0.58) | KDRROCK2AURKBEPHA2FLT4 | |
| SCHEMBL5745576 | 0.75 | KDR (0.44) | KDRROCK2AURKBEPHA2FLT4 | |
| SCHEMBL5880323 | 0.75 | KDR (0.49) | KDRROCK2AURKBEPHA2FLT4 | |
| SCHEMBL5880325 | 0.75 | KDR (0.50) | KDRROCK2AURKBEPHA2FLT4 | |
| SCHEMBL1334456 | 0.74 | KDR (1.00) | KDRROCK2AURKBEPHA2FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061602-A1 | ISOINDOLINONE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-10 | — | — | WO | disclosed |