Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.44 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | PLK4 | O00444 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | ROS1 | P08922 | 2/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | FRK | P42685 | 2/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.44 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.44 |
| ▸ | SRMS | Q9H3Y6 | 2/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5750826 | 0.92 | KDR (0.51) | KDRROCK2RPS6KB1ROCK1TAOK1 | |
| SCHEMBL5880323 | 0.87 | KDR (0.49) | KDRROCK2RPS6KB1ROCK1TAOK1 | |
| SCHEMBL5746369 | 0.85 | KDR (0.48) | KDRROCK2RPS6KB1ROCK1TAOK1 | |
| SCHEMBL1335620 | 0.79 | KDR (0.67) | KDRROCK2RPS6KB1ROCK1TAOK1 | |
| SCHEMBL5795104 | 0.76 | KDR (0.57) | KDRROCK2RPS6KB1ROCK1TAOK1 | |
| SCHEMBL2733404 | 0.75 | KDR (0.59) | KDRROCK2RPS6KB1ROCK1TAOK1 | |
| SCHEMBL1335499 | 0.72 | KDR (0.78) | KDRROCK2RPS6KB1ROCK1TAOK1 | |
| SCHEMBL28217568 | 0.72 | GRM4 (0.43) | RPS6KB1 | |
| SCHEMBL5880221 | 0.71 | KDR (0.49) | KDRROCK2RPS6KB1ROCK1TAOK1 | |
| SCHEMBL1335538 | 0.71 | KDR (0.72) | KDRROCK2RPS6KB1ROCK1TAOK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633710-A1 | ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS | Abbott Laboratories (US) | 2006-03-15 | — | — | EP | claimed |
| WO-2004108672-A1 | ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-16 | — | — | WO | claimed |