Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732328 | 0.88 | KCNJ1 (0.53) | KCNJ1KCNH2 | |
| SCHEMBL15192799 | 0.85 | KCNJ1 (0.51) | KCNJ1KCNH2 | |
| SCHEMBL15824652 | 0.84 | KMT2A (0.46) | KCNJ1KCNH2 | |
| SCHEMBL2732692 | 0.78 | KCNH2 (0.63) | KCNJ1KCNH2 | |
| SCHEMBL4549579 | 0.77 | KCNH2 (0.80) | KCNJ1KCNH2 | |
| SCHEMBL15191837 | 0.77 | KMT2A (0.55) | KCNJ1KCNH2 | |
| SCHEMBL2731496 | 0.76 | KCNJ1 (0.42) | KCNJ1KCNH2 | |
| SCHEMBL15191714 | 0.75 | KCNH2 (0.60) | KCNJ1KCNH2 | |
| SCHEMBL2732275 | 0.74 | KCNH2 (0.57) | KCNJ1KCNH2 | |
| SCHEMBL4549658 | 0.70 | KCNH2 (0.74) | KCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632464-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |