Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.57 |
| ▸ | KCNJ1 | P48048 | 17/20 | 0.51 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10287706 | 0.91 | KCNH2 (0.57) | KCNH2KCNJ1SSTR2 | |
| SCHEMBL15196763 | 0.87 | KCNH2 (0.54) | KCNH2KCNJ1SSTR2 | |
| Hydrochloric Acid SCHEMBL2732361 | 0.86 | KCNH2 (0.53) | KCNH2KCNJ1SSTR2 | |
| SCHEMBL2732030 | 0.84 | GPR119 (0.54) | KCNH2KCNJ1SSTR2 | |
| SCHEMBL2732692 | 0.83 | KCNH2 (0.63) | KCNH2KCNJ1 | |
| SCHEMBL2732279 | 0.82 | KCNJ1 (0.57) | KCNH2KCNJ1 | |
| SCHEMBL15191714 | 0.80 | KCNH2 (0.60) | KCNH2KCNJ1 | |
| SCHEMBL4549576 | 0.76 | KCNH2 (0.81) | KCNH2KCNJ1 | |
| SCHEMBL15191837 | 0.76 | KMT2A (0.55) | KCNH2KCNJ1 | |
| SCHEMBL2733641 | 0.74 | KCNJ1 (0.54) | KCNH2KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632464-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |