Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19389590 | 0.87 | PRSS1 (0.43) | APPPRSS1TPSAB1ALDH1A1HPGD | |
| SCHEMBL24835091 | 0.83 | PRSS1 (0.47) | APPPRSS1TPSAB1ALDH1A1HPGD | |
| SCHEMBL11982008 | 0.80 | PRSS1 (0.45) | APPPRSS1TPSAB1ALDH1A1HPGD | |
| SCHEMBL19035541 | 0.80 | APP (0.49) | APPALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL24968118 | 0.80 | ALDH1A1 (0.58) | ALDH1A1HPGDNPC1MAPK1KMT2A | |
| SCHEMBL10224011 | 0.79 | F13A1 (0.44) | APPPRSS1TPSAB1ALDH1A1HPGD | |
| SCHEMBL25092050 | 0.78 | PRSS1 (0.43) | APPPRSS1TPSAB1ALDH1A1HPGD | |
| SCHEMBL12285735 | 0.78 | ALDH1A1 (0.60) | APPALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL21163456 | 0.78 | APP (0.46) | APPPRSS1TPSAB1ALDH1A1HPGD | |
| SCHEMBL13596562 | 0.77 | F13A1 (0.43) | APPPRSS1TPSAB1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024138128-A2 | CEREBLON DEGRADER CONJUGATES, AND USES THEREOF | GENENTECH, INC. (US) | 2024-06-27 | — | — | WO | disclosed |