SCHEMBL27345630

SCHEMBL27345630

COc1cc(Cn2cccn2)cc2onc(NSc3cccc(NC4CCB(C#N)CC4)c3)c12

nearest known ligand 0.50

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ KAT7 O95251 20/20 0.50
▸ KAT6A Q92794 20/20 0.50
▸ KAT6B Q8WYB5 12/20 0.50
▸ KAT8 Q9H7Z6 12/20 0.50
▸ KAT5 Q92993 11/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27345697 0.88 KAT7 (0.53) KAT7KAT6AKAT6BKAT8KAT5
SCHEMBL27345673 0.88 KAT6A (0.53) KAT7KAT6AKAT6BKAT8KAT5
SCHEMBL27343885 0.79 KAT7 (0.61) KAT7KAT6AKAT6BKAT8KAT5
SCHEMBL27345558 0.78 KAT7 (0.53) KAT7KAT6AKAT6BKAT8KAT5
SCHEMBL27345595 0.77 KAT7 (0.53) KAT7KAT6AKAT6BKAT8KAT5
SCHEMBL22817402 0.76 KAT7 (0.68) KAT7KAT6AKAT6BKAT8KAT5
SCHEMBL27345649 0.76 KAT7 (0.51) KAT7KAT6AKAT6BKAT8KAT5
SCHEMBL27343902 0.76 KAT7 (0.55) KAT7KAT6AKAT6BKAT8KAT5
SCHEMBL27345764 0.75 KAT7 (0.53) KAT7KAT6AKAT6BKAT8KAT5
SCHEMBL27344195 0.75 KAT7 (0.51) KAT7KAT6AKAT6BKAT8KAT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023245150-A1 KAT6 TARGETING COMPOUNDS WITH UBIQUITIN LIGASE BINDING MOIETY PRELUDE THERAPEUTICS INCORPORATED (US) 2023-12-21 — — WO disclosed
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