SCHEMBL27345673

SCHEMBL27345673

COc1cc(Cn2cccn2)cc2onc(NSc3cccc(NC4CCN(C)CC4)c3)c12

nearest known ligand 0.53

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ KAT6A Q92794 20/20 0.53
▸ KAT7 O95251 19/20 0.53
▸ KAT6B Q8WYB5 13/20 0.53
▸ KAT5 Q92993 13/20 0.53
▸ KAT8 Q9H7Z6 13/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27345697 0.91 KAT7 (0.53) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL27345630 0.88 KAT7 (0.50) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL27345558 0.84 KAT7 (0.53) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL27343885 0.82 KAT7 (0.61) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL27345595 0.81 KAT7 (0.53) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL27345531 0.81 KAT6A (0.51) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL27343902 0.80 KAT7 (0.55) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL27344195 0.79 KAT7 (0.51) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL22817402 0.79 KAT7 (0.68) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL27344972 0.79 KAT7 (0.52) KAT6AKAT7KAT6BKAT5KAT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023245150-A1 KAT6 TARGETING COMPOUNDS WITH UBIQUITIN LIGASE BINDING MOIETY PRELUDE THERAPEUTICS INCORPORATED (US) 2023-12-21 — — WO disclosed
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