Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 0.39 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL5163639 | 0.86 | SSTR4 (0.36) | SLC6A2SLC6A4SLC6A3SSTR4TSHR | |
| Formic Acid SCHEMBL25180656 | 0.82 | SSTR4 (0.33) | SSTR4 | |
| SCHEMBL2303916 | 0.82 | — | — | |
| SCHEMBL16695 | 0.82 | — | — | |
| SCHEMBL1771223 | 0.82 | — | — | |
| SCHEMBL6023366 | 0.82 | — | — | |
| Propionic Acid SCHEMBL3286568 | 0.81 | FFAR3 (0.37) | SLC6A2SLC6A4SLC6A3SSTR4 | |
| SCHEMBL16569981 | 0.81 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3SSTR4 | |
| Trifluoroacetic Acid SCHEMBL2268475 | 0.80 | SSTR4 (0.36) | SLC6A2SLC6A3SSTR4 | |
| Lactic Acid SCHEMBL25180586 | 0.80 | TP53 (0.39) | SLC6A2SLC6A4SSTR4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1042028-C | Morpholine derivative | YAMANOUCHI PHARMA CO LTD (JP) | 1999-02-10 | — | — | CN | claimed |
| CN-1117729-A | morpholine derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1996-02-28 | — | — | CN | claimed |