Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | CASP3 | P42574 | 5/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 5/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 5/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 5/20 | 0.53 |
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | UBE2N | P61088 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2735321 | 0.82 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL21568165 | 0.77 | KMT2A (0.67) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL4915916 | 0.73 | RAB9A (0.83) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL4912955 | 0.73 | DHODH (0.76) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL2735273 | 0.71 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL27259424 | 0.71 | KMT2A (0.54) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL30945507 | 0.70 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL6688359 | 0.70 | CNR1 (0.68) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL2735283 | 0.70 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL4917553 | 0.70 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20100136136-A1 | JAK-2 Modulators and Methods of Use | EXELIXIS, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| US-20100136136-A1 | JAK-2 Modulators and Methods of Use | EXELIXIS, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| WO-2008042282-A2 | IMIDAZOLE-4, 5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | EXELIXIS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100136136-A1 | JAK-2 Modulators and Methods of Use | JAK2, JAK1, JAK3 | NPC1 3307/4885RAB9A 2213/4885SMN1; SMN2 2516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.