Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214375 | 0.94 | ALDH1A1 (0.39) | CHEK2ALDH1A1SMN1; SMN2KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL214583 | 0.94 | ALDH1A1 (0.39) | CHEK2ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL10267512 | 0.91 | CHEK2 (0.39) | CHEK2ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL14222391 | 0.91 | HRH4 (0.44) | CHEK2ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL2735419 | 0.88 | CHEK2 (0.41) | CHEK2ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL2735440 | 0.87 | CHEK2 (0.47) | CHEK2ALDH1A1MAPTKMT2AMAPK1 | |
| SCHEMBL14222346 | 0.87 | ALDH1A1 (0.40) | CHEK2ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL214621 | 0.85 | ALDH1A1 (0.39) | CHEK2ALDH1A1SMN1; SMN2KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL216278 | 0.85 | ALDH1A1 (0.39) | CHEK2ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL216261 | 0.84 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2KDM4EMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20100136136-A1 | JAK-2 Modulators and Methods of Use | EXELIXIS, INC. (US) | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100136136-A1 | JAK-2 Modulators and Methods of Use | JAK2, JAK1, JAK3 | CHEK2 412/4885ALDH1A1 4295/4885SMN1; SMN2 2516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.