SCHEMBL27356433

SCHEMBL27356433

COC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)OC1(C)CC2CC(C)CC(NCC(=O)N3Cc4ccc(F)cc4C3)(C2)C1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ DPP8 Q6V1X1 17/20 0.46
▸ DPP9 Q86TI2 17/20 0.46
▸ MEN1 O00255 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ HCRTR1 O43613 1/20 0.41
▸ GLMN Q92990 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30685268 0.90 DPP8 (0.58) DPP8DPP9GLMN
SCHEMBL27356442 0.90 DPP8 (0.58) DPP8DPP9GLMN
SCHEMBL31732775 0.90 DPP8 (0.58) DPP8DPP9GLMN
SCHEMBL27356459 0.83 DPP8 (0.56) DPP8DPP9GLMN
SCHEMBL30685219 0.83 DPP8 (0.59) DPP8DPP9GLMN
Lithium Ion SCHEMBL30685032 0.82 DPP8 (0.58) DPP8DPP9GLMN
SCHEMBL27356404 0.82 DPP8 (0.54) DPP8DPP9GLMN
SCHEMBL27356560 0.77 KMT2A (0.48) MEN1KMT2AHCRTR1
SCHEMBL27356064 0.77 DPP9 (0.74) DPP8DPP9GLMN
SCHEMBL27356167 0.75 DPP8 (0.75) DPP8DPP9GLMN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023233024-A1 DPP9 BINDING COMPOUNDS UNIVERSITEIT ANTWERPEN (BE) 2023-12-07 — — WO disclosed
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