Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL37382 | 0.89 | ALDH1A1 (0.68) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL9029750 | 0.88 | F2 (0.53) | TDP1KMT2ASLC6A2SLC6A3LMNA | |
| Ammonia Solution, Strong SCHEMBL9998884 | 0.87 | ALDH1A1 (0.65) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| Bicarbonate SCHEMBL29183459 | 0.87 | ALDH1A1 (0.65) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| Water SCHEMBL8217838 | 0.87 | ALDH1A1 (0.65) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| E1501 SCHEMBL28101210 | 0.85 | ALDH1A1 (0.81) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL17788435 | 0.84 | ALDH1A1 (0.57) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL550350 | 0.82 | ALDH1A1 (0.55) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL934017 | 0.82 | ALDH1A1 (0.55) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL27400293 | 0.82 | ALDH1A1 (0.55) | ALDH1A1TDP1KMT2AMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1040210-C | Fused benzazepine derivative and pharmaceutical composition containing the same | YAMANOUCHI PHARMA CO LTD (JP) | 1998-10-14 | — | — | CN | disclosed |
| CN-1127508-A | Fused benzazepine * derivatives and pharmaceutical compositions thereof | YAMANOUCHI PHARMA CO LTD (JP) | 1996-07-24 | — | — | CN | disclosed |