Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 13/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27359527 | 0.90 | FYN (0.62) | MAPKAPK5FYNPTK6PIM1TTK | |
| SCHEMBL27254073 | 0.89 | FYN (0.65) | MAPKAPK5FYNADRB1PTK6MAPT | |
| SCHEMBL27359536 | 0.84 | MAPKAPK5 (0.54) | MAPKAPK5FYNCDK9 | |
| SCHEMBL8246471 | 0.82 | AURKA (0.62) | MAPKAPK5FYNPTK6AURKB | |
| SCHEMBL32666593 | 0.81 | FYN (0.54) | MAPKAPK5FYNADRB1PTK6LCK | |
| SCHEMBL30806186 | 0.80 | MAPKAPK5 (0.58) | MAPKAPK5FYNCDK9MAPT | |
| SCHEMBL27254182 | 0.79 | MAPKAPK5 (0.70) | MAPKAPK5FYN | |
| SCHEMBL14536795 | 0.79 | MAPKAPK5 (0.54) | MAPKAPK5FYNPTK6AURKB | |
| SCHEMBL4392693 | 0.77 | MAPKAPK5 (0.68) | MAPKAPK5FYNTTK | |
| SCHEMBL2071019 | 0.76 | MAPKAPK5 (0.80) | MAPKAPK5FYNPTK6AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024026260-A1 | SUBSTITUTED IMIDAZOPYRAZINE COMPOUNDS AS IRAK3 BINDERS | CELGENE CORPORATION (US) | 2024-02-01 | — | — | WO | disclosed |