SCHEMBL27359772

SCHEMBL27359772

Cn1nc2cc(F)ccc2c1C#N

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 2/20 0.38
HTT P42858 2/20 0.34
KDM4E B2RXH2 1/20 0.34
ALK Q9UM73 7/20 0.33
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32
NCOA1 Q15788 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NCOA3 Q9Y6Q9 1/20 0.32
MIF P14174 1/20 0.32
MEN1 O00255 1/20 0.32
HCRTR1 O43613 1/20 0.32
KMT2A Q03164 1/20 0.32
JAK2 O60674 1/20 0.31
NR1I2 O75469 1/20 0.31
SLC34A2 O95436 1/20 0.31
EGFR P00533 1/20 0.31
CD74 P04233 1/20 0.31
NTRK1 P04629 1/20 0.31
FES P07332 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27359766 0.87 PDE10A (0.38) PDE10AHTTKDM4EALKLMNA
SCHEMBL27359775 0.80 KMT2A (0.40) PDE10AHTTKDM4EMEN1KMT2A
SCHEMBL27359756 0.80 PDE10A (0.38) PDE10AHTTMAPTSMN1; SMN2MEN1
SCHEMBL27359782 0.80 PDE10A (0.41) PDE10AKDM4EMAPTSMN1; SMN2KCNH2
SCHEMBL27359909 0.76 CSNK2A1 (0.37)
SCHEMBL9389564 0.75 KDM4E (0.42) HTTKDM4EMAPTMEN1KMT2A
SCHEMBL13106176 0.75 KIT (0.44) PDE10AHTTKDM4EMEN1HCRTR1
SCHEMBL27359781 0.75 LRRK2 (0.39)
SCHEMBL27359780 0.75 HCAR3 (0.47) KDM4EMAPTSMN1; SMN2MEN1KMT2A
SCHEMBL27359790 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024026536-A1 ANTIVIRAL COMPOUNDS AND USES THEREOF GRIFFITH UNIVERSITY (AU) 2024-02-08 WO disclosed