Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 5/20 | 0.49 |
| ▸ | CCND1 | P24385 | 13/20 | 0.49 |
| ▸ | CDK2 | P24941 | 11/20 | 0.49 |
| ▸ | CDK4 | P11802 | 9/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 7/20 | 0.49 |
| ▸ | CCND3 | P30281 | 5/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 2/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.49 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.49 |
| ▸ | MARK3 | P27448 | 2/20 | 0.49 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.49 |
| ▸ | MARK4 | Q96L34 | 2/20 | 0.49 |
| ▸ | NUAK2 | Q9H093 | 2/20 | 0.49 |
| ▸ | MARK1 | Q9P0L2 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27358291 | 0.89 | CCND1 (0.51) | TTKCCND1CDK2CDK4CCNE1 | |
| SCHEMBL25123507 | 0.86 | CCND1 (0.45) | TTKCCND1CDK2CDK4CCNE1 | |
| SCHEMBL29991330 | 0.86 | CDK4 (0.55) | CCND1CDK2CDK4CCNE1CDK6 | |
| SCHEMBL25122954 | 0.86 | CDK4 (0.55) | CCND1CDK2CDK4CCNE1CDK6 | |
| SCHEMBL25123480 | 0.86 | CCND1 (0.47) | TTKCCND1CDK2CDK4CCNE1 | |
| SCHEMBL29991840 | 0.86 | CCND1 (0.47) | TTKCCND1CDK2CDK4CCNE1 | |
| SCHEMBL25123157 | 0.85 | CCND1 (0.51) | TTKCCND1CDK2CDK4CCNE1 | |
| SCHEMBL29991408 | 0.85 | CCND1 (0.51) | TTKCCND1CDK2CDK4CCNE1 | |
| SCHEMBL27358289 | 0.85 | EGFR (0.48) | TTKCCND1CDK2CDK4CCNE1 | |
| SCHEMBL27360239 | 0.83 | CDK4 (0.68) | CCND1CDK2CDK4CCNE1CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024039903-A2 | CDK2 INHIBITORS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2024-02-22 | — | — | WO | disclosed |