Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27420794 | 1.00 | TSHR (0.35) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL26103710 | 1.00 | TSHR (0.35) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL27578499 | 0.98 | TSHR (0.34) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL27408631 | 0.98 | TSHR (0.34) | TSHRMAPK1HSD17B10TDP1THRB | |
| Hydrochloric Acid SCHEMBL27263377 | 0.98 | THRB (0.37) | TSHRMAPK1HSD17B10TDP1THRB | |
| Benzene SCHEMBL27313499 | 0.98 | TSHR (0.34) | TSHRMAPK1HSD17B10TDP1THRB | |
| Bicarbonate SCHEMBL27876876 | 0.98 | TSHR (0.34) | TSHRMAPK1HSD17B10TDP1THRB | |
| Acetic Acid SCHEMBL27563817 | 0.96 | TSHR (0.33) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL27529910 | 0.96 | TSHR (0.33) | TSHRMAPK1HSD17B10TDP1THRB | |
| Cyclohexane SCHEMBL27296677 | 0.96 | TSHR (0.33) | TSHRMAPK1HSD17B10TDP1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107235867-A | It is used as the aryl sultam derivative of RORc conditioning agents | 弗·哈夫曼-拉罗切有限公司 | 2017-10-10 | — | — | CN | claimed |
| CN-104470917-B | Aryl sultam derivatives as RORc modulators | 弗·哈夫曼-拉罗切有限公司 | 2017-08-04 | — | — | CN | claimed |
| CN-106083943-A | Glucopyranosyl derivative and preparation method and application thereof | 广东东阳光药业有限公司 | 2016-11-09 | — | — | CN | claimed |
| CN-105669642-A | Revaprzan hydrochloride preparation method | 江苏天士力帝益药业有限公司 | 2016-06-15 | — | — | CN | claimed |
| CN-105198838-A | Preparation method of repaglinide | Henan purui pharmaceutical co ltd | 2015-12-30 | — | — | CN | claimed |
| CN-104557778-A | Preparation method and application of repaglinide | CAI LUN | 2015-04-29 | — | — | CN | claimed |
| CN-102633750-A | One-pot method for synthesizing repaglinide for treating diabetes | Zhejiang anglikang pharmaceutical co ltd | 2012-08-15 | — | — | CN | claimed |
| CN-101772491-A | Repaglinide substantially free of dimer impurity | ACTAVIS GROUP PTC EHF | 2010-07-07 | — | — | CN | claimed |
| CN-1097591-C | Process for preparing pyrimidine derivatives | YUHAN CORP (KR) | 2003-01-01 | — | — | CN | claimed |
| CN-1217722-A | Process for preparing pyrimidine derivatives | YUHAN CORP (KR) | 1999-05-26 | — | — | CN | claimed |
| CN-105579450-B | Novel indolizine compounds, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2017-12-12 | — | — | CN | disclosed |
| CN-107108552-A | Heterocyclic kinase inhibitors | 百时美施贵宝公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-107011272-A | Pyrazines derivatives | 霍夫曼-拉罗奇有限公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-107011362-A | A kind of synthetic method of lavo-ofloxacin isomeric compound | 扬子江药业集团江苏海慈生物药业有限公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-107001278-A | Tetrahydro isoquinoline derivative | UCB生物制药私人有限公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-1097591-C | Process for preparing pyrimidine derivatives | YUHAN CORP (KR) | 2003-01-01 | — | — | CN | disclosed |
| CN-1056612-C | Process for epoxidation of prochiral olefins, catalyst for use in the process | SMITHKLINE BEECHAM PLC (GB) | 2000-09-20 | — | — | CN | disclosed |
| CN-1217722-A | Process for preparing pyrimidine derivatives | YUHAN CORP (KR) | 1999-05-26 | — | — | CN | disclosed |
| CN-1155281-A | Noval pyrimidine derivatives and prepn. processes thereof | YUHAN CORP (KR) | 1997-07-23 | — | — | CN | disclosed |
| CN-1145623-A | Process for epoxidation of prochiral olefins, catalyst for use in the process and intermediates for making the catalyst | SMITHKLINE BEECHAM PLC (GB) | 1997-03-19 | — | — | CN | disclosed |