Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.45 |
| ▸ | CA1 | P00915 | 4/20 | 0.45 |
| ▸ | CA2 | P00918 | 4/20 | 0.45 |
| ▸ | CA4 | P22748 | 4/20 | 0.45 |
| ▸ | CA9 | Q16790 | 4/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 4/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27362078 | 0.84 | HDAC6 (0.59) | CA12CA1CA2CA4CA9 | |
| SCHEMBL27361338 | 0.76 | HDAC6 (0.61) | CA12CA1CA2CA4CA9 | |
| SCHEMBL27361975 | 0.76 | HDAC6 (0.68) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL27361273 | 0.76 | HDAC6 (0.51) | CA12CA1CA2CA4CA9 | |
| SCHEMBL10876536 | 0.75 | CA12 (0.42) | CA12CA1CA2CA4CA9 | |
| SCHEMBL15452620 | 0.74 | CNR2 (0.53) | CA12CA1CA2CA4CA9 | |
| SCHEMBL27361270 | 0.68 | HDAC6 (0.53) | CA12CA1CA2CA4CA9 | |
| SCHEMBL27361274 | 0.68 | HDAC2 (0.45) | CA12CA1CA2CA4CA9 | |
| SCHEMBL27361448 | 0.68 | HDAC6 (0.71) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL27362059 | 0.67 | NAMPT (0.39) | CA12CA1CA2CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024028654-A2 | HISTONE DEACETYLASE INHIBITORS AND USE OF THE SAME | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2024-02-08 | — | — | WO | disclosed |