Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | GCK | P35557 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CD38 | P28907 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL595105 | 0.77 | MAPT (0.52) | SMN1; SMN2NPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL595893 | 0.74 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNANPC1RAB9AMEN1 | |
| SCHEMBL25297161 | 0.73 | KMT2A (0.44) | LMNANPC1RAB9AMEN1KMT2A | |
| SCHEMBL22021179 | 0.72 | ALDH1A1 (0.36) | SMN1; SMN2LMNANPC1RAB9AKMT2A | |
| SCHEMBL595719 | 0.72 | MEN1 (0.47) | SMN1; SMN2LMNANPC1RAB9AMEN1 | |
| SCHEMBL1885511 | 0.71 | PIK3CD (0.47) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL31593989 | 0.71 | AQP4 (0.46) | SMN1; SMN2LMNANPC1RAB9AKMT2A | |
| SCHEMBL1884261 | 0.71 | PIK3CG (0.38) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3759738 | 0.70 | GRM1 (0.49) | GRM1GCKROCK2SMN1; SMN2LMNA | |
| SCHEMBL29089052 | 0.70 | PIK3CG (0.39) | SMN1; SMN2LMNANPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024050433-A1 | ALLOSTERIC MODULATORS OF ANDROGEN RECEPTOR COACTIVATOR RECRUITMENT FOR CRPC THERAPY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2024-03-07 | — | — | WO | disclosed |