Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND1 | P24385 | 13/20 | 0.50 |
| ▸ | CDK2 | P24941 | 12/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.50 |
| ▸ | CDK4 | P11802 | 8/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.50 |
| ▸ | CCND3 | P30281 | 3/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.50 |
| ▸ | CDK9 | P50750 | 2/20 | 0.50 |
| ▸ | TTK | P33981 | 5/20 | 0.47 |
| ▸ | PRKDC | P78527 | 3/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27370551 | 0.89 | CCND1 (0.47) | CCND1CDK2CDK6CDK4CCNE1 | |
| SCHEMBL30837012 | 0.85 | CCND1 (0.51) | CCND1CDK2CDK6CDK4CCNE1 | |
| SCHEMBL27229160 | 0.85 | CCND1 (0.51) | CCND1CDK2CDK6CDK4CCNE1 | |
| SCHEMBL30836970 | 0.83 | CDK2 (0.53) | CCND1CDK2CDK6CDK4CCNE1 | |
| SCHEMBL27229159 | 0.83 | CDK2 (0.53) | CCND1CDK2CDK6CDK4CCNE1 | |
| SCHEMBL27357557 | 0.82 | CCND1 (0.49) | CCND1CDK2CDK6CDK4CCNE1 | |
| SCHEMBL27360177 | 0.81 | TTK (0.49) | CCND1CDK2CDK6CDK4CCNE1 | |
| SCHEMBL27358626 | 0.81 | CCND1 (0.54) | CCND1CDK2CDK6CDK4CCNE1 | |
| SCHEMBL25122980 | 0.79 | CDK2 (0.57) | CCND1CDK2CDK6CDK4CCNE1 | |
| SCHEMBL29990907 | 0.79 | CDK2 (0.57) | CCND1CDK2CDK6CDK4CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024039903-A2 | CDK2 INHIBITORS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2024-02-22 | — | — | WO | disclosed |