Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8139218 | 0.83 | SLC6A2 (0.44) | GAAMEN1KMT2ALMNACYP19A1 | |
| SCHEMBL3629431 | 0.78 | CYP17A1 (0.36) | GAAMEN1KMT2ALMNAMET | |
| SCHEMBL17243686 | 0.76 | GAA (0.54) | GAAMEN1KMT2AMET | |
| SCHEMBL11538981 | 0.69 | GAA (0.43) | GAAMEN1KMT2ALMNACYP19A1 | |
| SCHEMBL4732529 | 0.65 | DDB1 (0.59) | GAALMNACYP2D6KDM4E | |
| SCHEMBL12501011 | 0.65 | GAA (1.00) | GAAMEN1KMT2AMET | |
| SCHEMBL11795284 | 0.64 | GAA (0.46) | GAAMEN1KMT2ALMNACYP19A1 | |
| SCHEMBL11540241 | 0.62 | CYP19A1 (0.51) | MEN1KMT2ALMNACYP19A1CYP2D6 | |
| SCHEMBL4427312 | 0.62 | ALDH1A1 (0.43) | GAAKMT2ALMNASRCKDM4E | |
| SCHEMBL4101771 | 0.61 | DBH (0.62) | MEN1KMT2ACYP2D6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1068590-C | 1, 3-dihydro -1 -(phonylalkenyl) -2H -imidazol -2 -one derivatives having PDEIV and cytokine inhibiting activity | JANSSEN PHARMACEUTICA NV (BE) | 2001-07-18 | — | — | CN | disclosed |
| CN-1181071-A | 1, 3-dihydro-1- (phenylalkenyl) -2H-imidazol-2-one derivatives having PDEIV and cytokine inhibitory activity | JANSSEN PHARMACEUTION N V (BE) | 1998-05-06 | — | — | CN | disclosed |