Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27363823 | 0.87 | TDP1 (0.61) | SMN1; SMN2TSHRTDP1AKR1C3MAPT | |
| SCHEMBL19187554 | 0.86 | TDP1 (0.73) | SMN1; SMN2TSHRTDP1AKR1C3LMNA | |
| SCHEMBL22542070 | 0.83 | ALDH1A1 (0.69) | SMN1; SMN2TSHRTDP1AKR1C3LMNA | |
| SCHEMBL22814982 | 0.82 | ALDH1A1 (0.68) | SMN1; SMN2TSHRTDP1AKR1C3MAPT | |
| SCHEMBL22814979 | 0.82 | ALDH1A1 (0.68) | SMN1; SMN2TSHRTDP1AKR1C3MAPT | |
| SCHEMBL17888466 | 0.78 | ALDH1A1 (0.57) | SMN1; SMN2MEN1KMT2AALDH1A1POLB | |
| SCHEMBL14372238 | 0.78 | AKR1C3 (0.73) | SMN1; SMN2AKR1C3LMNAMAPTALDH1A1 | |
| SCHEMBL22814963 | 0.77 | MAPT (0.65) | SMN1; SMN2TSHRTDP1AKR1C3MAPT | |
| SCHEMBL22814983 | 0.77 | MAPT (0.61) | SMN1; SMN2TSHRTDP1AKR1C3MAPT | |
| SCHEMBL22814978 | 0.76 | MAPT (0.64) | SMN1; SMN2TSHRTDP1AKR1C3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054591-A1 | RAPIDLY ACCELERATED FIBROSARCOMA (RAF) DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |