SCHEMBL27365544

SCHEMBL27365544

CC(=O)Nc1cccc(-c2c[nH]c3ncnc(Oc4ccc(NC(=O)c5cccn(-c6ccc(F)cc6)c5=O)cc4)c23)c1

nearest known ligand 0.66

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MERTK Q12866 15/20 0.66
AXL P30530 14/20 0.66
TYRO3 Q06418 2/20 0.66
MET P08581 5/20 0.56
MST1R Q04912 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27365768 0.94 MERTK (0.65) MERTKAXLTYRO3METMST1R
SCHEMBL27365492 0.91 MERTK (0.77) MERTKAXLTYRO3MET
SCHEMBL31512159 0.91 MERTK (0.77) MERTKAXLTYRO3MET
SCHEMBL27365552 0.90 MERTK (0.65) MERTKAXLTYRO3METMST1R
SCHEMBL27365767 0.90 MERTK (0.66) MERTKAXLTYRO3METMST1R
SCHEMBL27366537 0.88 MERTK (0.67) MERTKAXLTYRO3MET
SCHEMBL32685072 0.88 MERTK (0.67) MERTKAXLTYRO3MET
SCHEMBL27365939 0.88 MERTK (0.66) MERTKAXLTYRO3METMST1R
SCHEMBL27365696 0.87 MERTK (0.62) MERTKAXLTYRO3MET
SCHEMBL27366130 0.87 MERTK (0.82) MERTKAXLTYRO3MET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed