SCHEMBL27365552

SCHEMBL27365552

O=C(Nc1ccc(Oc2ncnc3[nH]cc(-c4ccccc4)c23)cc1)c1cccn(-c2ccc(F)cc2)c1=O

nearest known ligand 0.65

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MERTK Q12866 14/20 0.65
AXL P30530 13/20 0.65
MET P08581 6/20 0.60
MST1R Q04912 1/20 0.60
TYRO3 Q06418 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27365696 0.93 MERTK (0.62) MERTKAXLMETTYRO3
SCHEMBL27365492 0.92 MERTK (0.77) MERTKAXLMETTYRO3
SCHEMBL31512159 0.92 MERTK (0.77) MERTKAXLMETTYRO3
SCHEMBL27365768 0.91 MERTK (0.65) MERTKAXLMETMST1RTYRO3
SCHEMBL27365697 0.90 MERTK (0.59) MERTKAXLMETMST1RTYRO3
SCHEMBL27365544 0.90 MERTK (0.66) MERTKAXLMETMST1RTYRO3
SCHEMBL27365767 0.89 MERTK (0.66) MERTKAXLMETMST1RTYRO3
SCHEMBL32685072 0.88 MERTK (0.67) MERTKAXLMETTYRO3
SCHEMBL27366537 0.88 MERTK (0.67) MERTKAXLMETTYRO3
SCHEMBL27365698 0.86 MERTK (0.58) MERTKAXLMETMST1RTYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed