Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 5/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ESRRA | P11474 | 1/20 | 0.40 |
| ▸ | LIPC | P11150 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8612829 | 0.89 | CFTR (0.46) | CFTRPLK1RXRANR1H2PPARG | |
| SCHEMBL13730307 | 0.87 | CFTR (0.60) | CFTRRXRANR1H2MRGPRX4CES2 | |
| Ammonia Solution, Strong SCHEMBL7107044 | 0.83 | PLK1 (0.52) | PLK1RXRANR1H2PPARDPPARA | |
| SCHEMBL477875 | 0.82 | CFTR (0.59) | CFTRRXRANR1H2MRGPRX4CES2 | |
| SCHEMBL22826631 | 0.81 | TYR (0.42) | CNR2CNR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1435026 | 0.81 | CFTR (0.57) | CFTRRXRANR1H2MRGPRX4CES2 | |
| SCHEMBL8612587 | 0.80 | CFTR (0.48) | CFTRRXRANR1H2PPARGPPARD | |
| SCHEMBL2358405 | 0.79 | PLK1 (0.51) | PLK1RXRANR1H2CNR2CES2 | |
| SCHEMBL4107553 | 0.79 | CFTR (0.55) | CFTRRXRANR1H2MRGPRX4CES2 | |
| Ammonia Solution, Strong SCHEMBL27818289 | 0.78 | KDM4E (0.51) | PLK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1064955-C | Fluorine-containing benzoylguanidines | MERCK PATENT GMBH (DE) | 2001-04-25 | — | — | CN | disclosed |
| CN-1143632-A | Fluorine-containing benzoylguanidines | MERCK PATENT GMBH (DE) | 1997-02-26 | — | — | CN | disclosed |