Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 8/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 3/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8612587 | 0.93 | CFTR (0.48) | CFTRCNR2RXRANR1H2SLC9A1 | |
| SCHEMBL9018659 | 0.92 | PLK1 (0.40) | CNR2PLK1SLC9A1 | |
| SCHEMBL8611582 | 0.90 | CFTR (0.51) | CFTRRXRANR1H2SLC9A1MRGPRX4 | |
| SCHEMBL27366276 | 0.89 | CFTR (0.54) | CFTRCNR2PLK1RXRANR1H2 | |
| SCHEMBL8609393 | 0.86 | HDAC3 (0.38) | CNR2SLC9A1PPARGMRGPRX4CNR1 | |
| SCHEMBL9018692 | 0.85 | SLC9A1 (0.41) | CFTRPLK1SLC9A1PPARGPPARD | |
| SCHEMBL9018680 | 0.81 | SLC9A1 (0.43) | CFTRSLC9A1 | |
| SCHEMBL8612247 | 0.81 | SLC9A1 (0.37) | CFTRSLC9A1 | |
| SCHEMBL9018723 | 0.80 | PRSS1 (0.40) | NR1H2PPARGNR1H3 | |
| SCHEMBL8612846 | 0.79 | MRGPRX4 (0.38) | CFTRMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5747539-A | Fluorine-containing benzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-05 | — | — | US | disclosed |