Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4935278 | 0.76 | KDM4E (0.37) | JAK3NPC1MAPTRAB9ATP53 | |
| SCHEMBL22118361 | 0.76 | JAK3 (0.47) | JAK3NPC1MAPTRAB9ATP53 | |
| SCHEMBL21981199 | 0.76 | JAK3 (0.47) | JAK3NPC1MAPTRAB9ATP53 | |
| SCHEMBL20862666 | 0.69 | JAK3 (0.55) | JAK3NPC1MAPTRAB9ATP53 | |
| SCHEMBL20862642 | 0.69 | JAK3 (0.55) | JAK3NPC1MAPTRAB9ATP53 | |
| SCHEMBL4932197 | 0.68 | KDM4E (0.37) | JAK3NPC1MAPTRAB9ATP53 | |
| SCHEMBL25668430 | 0.68 | JAK3 (0.53) | JAK3NPC1MAPTRAB9ATP53 | |
| SCHEMBL20775208 | 0.67 | ENPP1 (0.40) | — | |
| SCHEMBL19725048 | 0.67 | JAK3 (0.51) | JAK3NPC1MAPTRAB9ATP53 | |
| SCHEMBL3954391 | 0.67 | JAK3 (1.00) | JAK3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024049929-A2 | PANNEXIN-1 MODULATORS AND METHODS OF TREATING DISORDERS IN WHICH PANNEXIN-1 IS IMPLICATED | PANNEX THERAPEUTICS INC. (US) | 2024-03-07 | — | — | WO | disclosed |