Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4935278 | 0.80 | KDM4E (0.37) | KDM4EHTTMAP4K4MAPTNPC1 | |
| SCHEMBL27274962 | 0.73 | KDM4E (0.45) | KDM4EHTTMAP4K4MAPTNPC1 | |
| SCHEMBL27366298 | 0.68 | JAK3 (0.50) | KDM4EMAP4K4MAPTNPC1RAB9A | |
| SCHEMBL22118361 | 0.66 | JAK3 (0.47) | KDM4EMAP4K4MAPTNPC1RAB9A | |
| SCHEMBL21981199 | 0.66 | JAK3 (0.47) | KDM4EMAP4K4MAPTNPC1RAB9A | |
| SCHEMBL14325245 | 0.65 | GRM4 (0.45) | KDM4EHTTMAP4K4MAPTNPC1 | |
| SCHEMBL20633244 | 0.65 | KDM4E (0.49) | KDM4EHTTMAP4K4MAPTNPC1 | |
| SCHEMBL4934412 | 0.65 | KDM4E (0.44) | KDM4ENPC1GAA | |
| SCHEMBL23515049 | 0.65 | GRM4 (0.43) | KDM4EHTTMAP4K4MAPTNPC1 | |
| SCHEMBL10136907 | 0.64 | ADRA1A (0.46) | KDM4EHTTMAP4K4MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312271-A1 | AZABENZIMIDAZOLYL COMPOUNDS | PFIZER INC. | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312271-A1 | AZABENZIMIDAZOLYL COMPOUNDS | AZI2, PAICS, UGT2B7 | KDM4E 793/4885HTT 3033/4885MAP4K4 2537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.