SCHEMBL27366367

SCHEMBL27366367

CC(=O)Nc1cccc(-c2c(-c3cnn(C)c3)oc3ncnc(Oc4ccc(NC(=O)c5cc6c(n(-c7ccc(F)cc7)c5=O)CCCC6=O)cc4)c23)c1

nearest known ligand 0.74

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
AXL P30530 19/20 0.74
MERTK Q12866 19/20 0.74
TYRO3 Q06418 4/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27366300 0.95 AXL (0.66) AXLMERTKTYRO3
SCHEMBL27366365 0.93 MERTK (0.73) AXLMERTKTYRO3
SCHEMBL27367386 0.90 AXL (0.75) AXLMERTKTYRO3
SCHEMBL27366369 0.88 MERTK (0.81) AXLMERTKTYRO3
SCHEMBL27366297 0.88 MERTK (0.65) AXLMERTKTYRO3
SCHEMBL27366944 0.86 MERTK (0.82) AXLMERTKTYRO3
SCHEMBL27367332 0.85 AXL (0.67) AXLMERTKTYRO3
SCHEMBL27365549 0.85 MERTK (1.00) AXLMERTKTYRO3
SCHEMBL27367033 0.84 MERTK (0.77) AXLMERTKTYRO3
SCHEMBL27366373 0.82 MERTK (0.83) AXLMERTKTYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed