SCHEMBL27367033

SCHEMBL27367033

CC(=O)Nc1cccc(-c2c(-c3cnn(C)c3)oc3ncnc(Oc4ccc(NC(=O)c5c(C)n(C)n(-c6ccc(F)cc6)c5=O)cc4)c23)c1

nearest known ligand 0.77

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MERTK Q12866 20/20 0.77
AXL P30530 19/20 0.77
TYRO3 Q06418 4/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27367032 0.92 MERTK (0.77) MERTKAXLTYRO3
SCHEMBL31512150 0.92 MERTK (0.77) MERTKAXLTYRO3
SCHEMBL27366944 0.90 MERTK (0.82) MERTKAXLTYRO3
SCHEMBL27366373 0.89 MERTK (0.83) MERTKAXLTYRO3
SCHEMBL27366369 0.88 MERTK (0.81) MERTKAXLTYRO3
SCHEMBL27365549 0.87 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL27365701 0.86 MERTK (0.80) MERTKAXLTYRO3
SCHEMBL27367024 0.84 MERTK (0.74) MERTKAXLTYRO3
SCHEMBL27366367 0.84 AXL (0.74) MERTKAXLTYRO3
SCHEMBL27366947 0.84 MERTK (0.73) MERTKAXLTYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed