Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.33 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.33 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27276581 | 0.72 | KDM4E (0.47) | KDM4EGAAMAPTHDAC1PRKCZ | |
| SCHEMBL27276191 | 0.71 | MAPT (0.49) | KDM4EGAAMAPTHDAC1HDAC3 | |
| SCHEMBL30734264 | 0.71 | KDM4E (0.40) | KDM4EGAAMAPTHDAC1HDAC2 | |
| SCHEMBL27275209 | 0.68 | KDM4E (0.37) | KDM4EGAAMAPTHDAC1PRKCZ | |
| SCHEMBL27276326 | 0.67 | KDM4E (0.51) | KDM4EGAAMAPTALOX15 | |
| SCHEMBL17678177 | 0.67 | MAPT (0.51) | KDM4EGAAMAPTHDAC1ALOX15 | |
| SCHEMBL20349191 | 0.67 | MAPT (0.51) | KDM4EGAAMAPTHDAC1HDAC2 | |
| SCHEMBL11964427 | 0.67 | GAA (0.51) | KDM4EGAAMAPTHDAC1HDAC2 | |
| SCHEMBL20837294 | 0.66 | MAPT (0.62) | KDM4EGAAMAPTALOX15 | |
| SCHEMBL2514778 | 0.64 | MAPT (0.56) | KDM4EGAAMAPTHDAC1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250439-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |