Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT5B | Q4FZB7 | 2/20 | 0.36 |
| ▸ | KMT5C | Q86Y97 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 7/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22043535 | 0.86 | KDM4E (0.46) | KDM4EGAAMAPTKMT5BKMT5C | |
| SCHEMBL30734310 | 0.79 | TP53 (0.47) | GAAMAPTL3MBTL1 | |
| SCHEMBL27276581 | 0.78 | KDM4E (0.47) | KDM4EGAAMAPTKMT5BKMT5C | |
| SCHEMBL17531762 | 0.73 | MEN1 (0.48) | LTA4HHDAC4ALDH1A1L3MBTL1 | |
| SCHEMBL27367073 | 0.71 | KDM4E (0.40) | KDM4EGAAMAPTHDAC1HDAC3 | |
| SCHEMBL1127714 | 0.69 | LTA4H (0.42) | LTA4HHDAC4ALDH1A1 | |
| SCHEMBL1829295 | 0.69 | ALDH1A1 (0.53) | KDM4EMAPTLTA4HHDAC4ALDH1A1 | |
| SCHEMBL27276191 | 0.68 | MAPT (0.49) | KDM4EGAAMAPTHDAC1HDAC3 | |
| SCHEMBL27275209 | 0.68 | KDM4E (0.37) | KDM4EGAAMAPTHDAC1HDAC3 | |
| SCHEMBL11964427 | 0.67 | GAA (0.51) | KDM4EGAAMAPTHDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250399-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |