SCHEMBL27367116

SCHEMBL27367116

CN/C=C(\C(=O)Nc1ccc(F)cc1)C(=O)Nc1ccc(Oc2ncnc3oc(-c4cnn(C)c4)c(-c4cccc(CN5CCOCC5)c4)c23)cc1

nearest known ligand 0.60

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MERTK Q12866 20/20 0.60
AXL P30530 17/20 0.60
TYRO3 Q06418 4/20 0.58
EGFR P00533 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27367248 0.81 MERTK (0.70) MERTKAXLTYRO3EGFR
SCHEMBL27367114 0.80 MERTK (0.70) MERTKAXLTYRO3
SCHEMBL27367122 0.79 MERTK (0.69) MERTKAXLTYRO3
SCHEMBL27367329 0.76 AXL (0.55) MERTKAXLTYRO3
SCHEMBL27366038 0.75 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL27367037 0.75 MERTK (0.83) MERTKAXLTYRO3
SCHEMBL27365850 0.75 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL27367020 0.74 MERTK (0.74) MERTKAXLTYRO3
SCHEMBL27366945 0.74 MERTK (0.73) MERTKAXLTYRO3
SCHEMBL27367024 0.74 MERTK (0.74) MERTKAXLTYRO3EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed