SCHEMBL27367326

SCHEMBL27367326

CN(C)Cc1cccc(-c2c(-c3cnn(C)c3)sc3ncnc(Oc4ccc(NC(=O)c5cccn(-c6ccc(F)cc6)c5=O)cc4)c23)c1

nearest known ligand 0.78

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
AXL P30530 20/20 0.78
MERTK Q12866 20/20 0.78
TYRO3 Q06418 4/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27367325 0.90 MERTK (0.77) AXLMERTKTYRO3
SCHEMBL32685181 0.88 MERTK (1.00) AXLMERTKTYRO3
SCHEMBL27365942 0.88 MERTK (1.00) AXLMERTKTYRO3
SCHEMBL27367329 0.83 AXL (0.55) AXLMERTKTYRO3
SCHEMBL31512155 0.82 MERTK (0.89) AXLMERTKTYRO3
SCHEMBL27366651 0.82 MERTK (0.89) AXLMERTKTYRO3
SCHEMBL27367390 0.82 MERTK (0.84) AXLMERTKTYRO3
SCHEMBL27366547 0.81 MERTK (1.00) AXLMERTKTYRO3
SCHEMBL27365850 0.81 MERTK (1.00) AXLMERTKTYRO3
SCHEMBL27367327 0.80 MERTK (0.63) AXLMERTKTYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed