Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL950968 | 0.79 | CYP3A4 (0.52) | CYP3A4CYP11B1CYP11B2CYP19A1IDO1 | |
| SCHEMBL21863400 | 0.79 | UHRF1 (0.46) | CYP2A6CYP1A2CYP2C9KMT2AUHRF1 | |
| SCHEMBL5861792 | 0.79 | UHRF1 (0.46) | MAPTCYP2A6MEN1KMT2AUHRF1 | |
| SCHEMBL4708730 | 0.78 | IDO1 (0.59) | CYP3A4CYP11B1CYP11B2CYP19A1IDO1 | |
| SCHEMBL26815031 | 0.77 | CYP11B1 (0.50) | CYP3A4CYP11B1CYP11B2CYP19A1IDO1 | |
| SCHEMBL12117429 | 0.76 | CYP11B1 (0.56) | CYP3A4CYP11B1CYP11B2CYP19A1IDO1 | |
| SCHEMBL872242 | 0.74 | IDO1 (0.64) | CYP3A4CYP11B1CYP11B2CYP19A1IDO1 | |
| SCHEMBL19296052 | 0.74 | CYP3A4 (0.59) | CYP3A4CYP11B1CYP11B2CYP19A1NCOA3 | |
| SCHEMBL14489499 | 0.74 | IDO1 (0.75) | CYP3A4CYP11B1CYP11B2CYP19A1IDO1 | |
| SCHEMBL26548539 | 0.74 | HRH4 (0.47) | CYP3A4CYP11B1CYP11B2CYP19A1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059665-A1 | DIMERIC COMPOUNDS AS INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2024-03-21 | — | — | WO | disclosed |